Immunohistochemical expression of Cyclooxygenase 2 reflects the proliferative activity in the epithelium of odontogenic lesions

Purpose: Odontogenic cysts and tumors comprise a major component of lesions the oral maxillofacial region. The pathogenesis these involves interaction between odontogenic epithelium ectomesenchyme. However, clinical behavior biological entities is unpredictable. aim this study was to evaluate role Cyclooxygenase 2 (COX-2) in prognostication lesions.Material method: : In formalin-fixed paraffin-embedded tissue section Keratocyst (n=10) Dentigerous cyst (n=10), Radicular unicystic ameloblastoma were immunohistochemically stained with COX-2 (NCL2-COX-2- 4H12) Ki 67 (Ki-67 GM001) using standard staining protocols. cytoplasmic expression all semi-quantitatively assessed. pattern among different statistical analyzed ANOVA test chi-square test.Results: All 40 that evaluated expressed immunohistochemically. A high number epithelial cells most keratocyst, radicular ameloblastomas. significantly (p=0.036) higher Unicystic Ameloblastomas compared dentigerous cyst.Conclusion: recognition by may indeed shed new light on mechanisms involved development benign yet aggressive jaws. An insight into molecular interactions occurring will aid better management lesions.